Broadway's Top Ten Musicals of the Decade

How many of the ten top grossing Broadway musicals listed below have you seen? If you are a music lover you probably seen them all. It is also most likely that one or two in the list you have seen twice in Broadway or in a movie. The following is the top ten list as reviewed by www.toptenreviews.com.

1. The Phantom of the Opera has been the longest-running show in the history of Broadway. Running continuously since 1988 – 21 years – it has been a consistent sell-out and favorite for many of those visiting New York City. The show tells the dramatic story of a disfigured man who haunts the Paris Opera House. He falls in love with Christine Daae and trains her to sing like an angel.

2. The Lion King maintains a place at the top of the lists for the 'longest-running musicals' and 'winners of many viewers’ choice awards.' The musical is mostly along the lines of the animated Disney movie and is appealing to young children and families.

3. Cats was the longest running show when it left the stage around 2003. The show has been translated into more than 20 languages and has been shown around the world. It tells the story of the Jellicle Cats’ and their life stories.

4. Les Miserables, based on the 1862 novel of the same title by Victor Hugo, is the longest running play in London. Set in the period of social unrest during the French Revolution, the themes of the book and play are discussed in high school classes the world over.

5. Wicked, though not as long-standing as some of these other productions, this new musical has the audience seeing green. It was selected by viewers as the best musical of 2007. The musical has broken box-office records around the world. It was also named by Time magazine as the “Best Musical of the Year”. Wicked tells the story of what Oz was like, long before Dorothy got there.

6. The Producers has won the most Tony Awards ever receiving 12 including Best Musical. Written by Mel Brooks the musical tells the story of two producers who try to make big on a scheme to oversell a flop of a show. But when the show becomes successful, it leads to some humorous moments.

7. A Chorus Line is an old classic that has been revived. The story has won several Tony Awards and has been around for a while, one of the longest-running musicals on Broadway. The audience meets 17 dancers that share their personal lives as they audition for a part in a chorus line.

8. Hairspray has taken home the Tony Award’s top six awards, only one of three musicals that have ever done so. The performance tells the story of the racial tensions in the 1960s and one girl’s campaign to racially integrate a famous TV show.

9. Rent is a rock musical that tells the story of poor young artists living in New York. The musical, along with winning a Tony Award for Best Musical has also won a Pulitzer Prize. Rent became famous for its appeal to a younger audience.

10. Chicago is based on the true stories of two celebrities who were on trial for murder and were found “not guilty”. Chicago is one of longest-running current Broadway productions on the stage.

Macrine and I have seen all except #6. Most recent Broadway musical in the news is Hamilton. Others musical shows that we have seen and enjoy that is not in the list are Miss Saigon and Bye Bye Birdie. Finally, here's a video of top ten Broadway Musicals that should be made into movies!

Ten Most Expensive Books for your Reading Pleasure

In my previous postings in my other blogs I have listed ten most expensive photographs, paintings, cars, homes and sculptures. Today I am listing the top ten most expensive books. Before I did my search, My educated guess for number 1 was either the Gutenberg Bible or the Birds of America by Audubon. Again, I was wrong and surprise to read the following list. This shows how ignorant I am about books. So before you open the link below, can you give me your educated guess on the number 1 most expensive book in the world.

http://www.worldstopmost.com/2017-2018-2019-2020/news/most-expensive-books-world-top-10-best-selling-popular-list/

Music and Mathematics: Have You Heard of Dr. Raul Sunico?

I have not been following the music scene in the Philippines. However, just the other day I received an E-mail from our current Philippines American Academy of Science & Engineering (PAASE) President, DR Joel Cuello, about one of the members of PAASE that is both a mathematician and a world famous pianist. His name is Dr. Raul Sunico. I have vaguely heard of his name, and had never heard him play. So I did some Internet search and here's a video of Dr Sunico that I enjoyed very much.


Here's a biography of Dr Sunico:

Raul M. Sunico graduated from the University of the Philippines with the degrees of Bachelor of Music (cum laude), Bachelor of Science in Mathematics, and Master of Statistics. A scholarship from former First Lady Imelda Romualdez-Marcos through the
Young Artists Foundation of the Philippines enabled him to finish his Master of Music degree from the Juilliard School in New York and a Doctor of Philosophy degree, major in piano Performance from the New York University. In 2005, he was also conferred a
Doctor of Humanities degree (honoris causa) by the Far Eastern University.

Sunico has given solo recitals in the United States, Canada, Mexico, India, Australia, Austria, France, Germany, Italy, Kosovo, Japan, Sri Lanka, South Korea, Poland, Spain, Netherlands, United Arab Emirates, Sweden, England, and the Philippines. He was the
soloist of the Moscow Philharmonic Orchestra, Transylvania Philharmonic Orchestra (Romania), Szczecin Philharmonic Orchestra (Poland), Towson Community Orchestra (Maryland, USA), Taipei Symphony Orchestra, Taiwan Normal University Wind Orchestra, Tokyo Sinfonia, Vietnam National Symphony Orchestra, Ho Chi Minh Symphony Orchestra, Philippine Philharmonic Orchestra, and other major Philippine orchestras.

Sunico is concurrently the President of the Cultural Center of the Philippines and Dean of the University of Santo Tomas Conservatory of Music. BRAVO!!

My first practical knowledge that there is a correlation between music and mathematics was in the early 1950's when I was a college student at the University of the Philippines. One of my many UPSCA ( UP student catholic action) friends was studying piano at the College of Music. She graduated with high honors from the College of Music. Later on she studied Mathematics and graduated with high honors again. She was then appointed as Instructor in Mathematics at the College of Liberal Arts. Her name: Mercy Lopez. I have no contact with her since then, but needless to say, I admired her very much and had a crush on her for being a talented pianist and mathematician.

Mercy Lopez at the Men's South Dorm Open House with Me and Room Mates, 1954

Below is a short video about Math and Music.



For additional details on music and math correlation read the following:
http://serendip.brynmawr.edu/exchange/serendipupdate/correlation-between-music-and-math-neurobiology-perspective

Treasured Photos of UPSCA and Fr John Delaney: 1952-1957

Newspaper Clippings on the Death of Fr John Delaney, 1956. Today is the 61st Anniversary of his death. For more details on his life and work in UP Diliman, read, http://davidbkatague.blogspot.com/2016/01/memories-of-my-college-years-in-up.html

The following are old photos I just discovered recently dating from 1952 to 1957 mostly of Macrine's and my UPSCA Activities. UPSCA is the University of the Philippines Student Catholic Action for those of you not familiar with the initial.

1953 UPSCA Choir

Barbecue Party after UPSCA Concert, UP Diliman, 1954

Marinduque Association, Silver Jubilee, Manila Hotel, 1957

UPSCA Social Works with Fr John Delaney, 1952

UPSCA Meeting with Fr Delaney and Tito Tino ( Fr. Constantino Nieva)-President of UPSCA, 1952

What's Hot ( Not New) in Parkinson Disease Therapy

Just recently, I learned that there is a new controlled released formulation of Carbo-Levodopa manufactured by Impax Pharmaceuticals called Rytary. Since my wife has PD I was very curious if switching from the immediate release formulation she is currently taking to this controlled release medication will benefit her. The following is an article published by the National Parkinson Foundation that I found very informative.

"The What’s Hot in Parkinson’s disease blog written in April 2013 featured a new extended release dopamine drug called IPX066. This new dopamine formulation achieved full FDA approval in January 2015. The drug is now sold under the name Rytary. At National Parkinson Foundation we frequently hear from Parkinson’s disease patients that current Carbidopa/levodopa medication preparations fail to adequately address disease-related symptoms. In this month’s What’s Hot column we will update you on important information on Rytary, and also offer a few tips for switching.

It is important to understand the reasons that an individual Parkinson’s disease patient may consider an extended release dopamine medication. The frequently cited medication related problems include:

1. Medication dosages taking too long to “kick in” and start working

2. Medication wearing off before the next scheduled medication dose

3. Severe on-off medication fluctuation periods (e.g. rapid cycling during the day ranging from feeling completely on medication to completely off medication)

4. Dyskinesia (too much movement, usually resulting from too high of a blood level of dopamine)

5. Too many pills:

6. Too many medication dosage intervals (e.g. taking medications every 1-2 hours throughout the waking day).

Patients may also have other disease related issues that levodopa preparations will not address, including walking, balance, talking, and thinking issues, but these will likely require a totally different approach than simple levodopa replacement or Rytary. Dr. Robert Hauser at the National Parkinson Foundation Center of Excellence at the University of South Florida, along with colleagues from 68 North American and European study sites, recently published a paper on a new extended release formulation of carbidopa/levodopa (IPX066 now called Rytary).

The new formulation of carbidopa/levodopa extended release (IPX066/Rytary), is different than its predecessors. It contains special beads designed to dissolve at different rates within the stomach and the intestines. The medication capsule was designed to provide longer lasting benefit for patients with Parkinson’s disease. The randomized study included 393 Parkinson’s disease patients who reported at least of 2.5 hours of “off time,” defined as periods when they felt the medication was not working. The authors aimed to improve the number of hours of “off time” each day for patients randomized to the new extended release formulation (IPX066/Rytary) as compared to the older and standard regular release carbidopa/levodopa. The results revealed that the group on extended release formulations took less overall medication dosages (3.6 vs. 5 doses per day); however they also took more total pills. The daily “off-time” improved by over an hour each day in the extended release formulation. Both medications in this trial were safe and well tolerated.

If we return to the six areas (listed above in bullet points) where Parkinson’s disease patients have been seeking improved medication formulations, Rytary was observed to improve issues in two categories: wearing off between dosages, and improvement by increasing the time interval between dosages. The results of the current study cannot be widely applied to patients with severe dyskinesia, severe on-off fluctuations, and later stage disease. The new extended release formulation also increased the total blood-stream levodopa exposure by 30-40% as compared to conventional immediate release levodopa. Increasing levodopa in the bloodstream is thought to decrease the threshold for dyskinesia, and this has been observed with other Parkinson’s drugs such as Entacapone and Stalevo. Although dosed less frequently, the extended release formulation can require more total pills per day (see FDA conversion table below). The authors of the Rytary study felt that a newer formulation of the same drug, which they anticipate will be used in future clinical practice, would allow for a decrease in pill number. 

In a recent interview with the lead author, Dr. Hauser, we addressed some of the important tips for switching to Rytary.
Though it is unknown who the “best” patients in clinical practice will be, it is suspected that patients with bothersome motor fluctuations, and patients taking a minimum of four 25/100 Sinemet regular or extended release (or the equivalent Madopar dosing) may be reasonable candidates.

Patients with motor fluctuations on three doses of Sinemet or Madopar could benefit, but a satisfactory benefit could possibly be obtained by adding a dose of Sinemet or Madopar rather than switching to Rytary. There may be select patients who can take a Rytary dose that is approximately three times the usual individual Sinemet or Madopar doses, and be able to maintain three times a day dosing at least for a period of time (i.e. before disease progression).

Dosages of Rytary are not interchangeable with other levodopa (Sinemet or Madopar) products. The capsules can be opened and the contents sprinkled onto foods such as apple sauce, if swallowing problems are present. The most important information for patients and families is to avoid magical thinking when switching to the Rytary formulation of levodopa. Further dose adjustments will be likely after the initial medication switch. It will be important for the patient, family, and doctor to discuss the symptoms and optimize and tweak dosages and intervals on the Rytary formulation.

Patients and families should be excited by the news of this new formulation of carbidopa/levodopa. However, patients and clinicians should be aware that there are limitations in the use of Rytary, and that caution should be exercised, especially because in select cases dyskinesia may manifest after switching. Dosages and dosage intervals of any formulation of carbidopa/levodopa, including Rytary, should be carefully adjusted at each clinic visit to address changes in Parkinson’s symptoms.

Patients may also be slightly disappointed that 3-4 capsules of Rytary may need to be taken at each dosage interval. The success or failure of dopamine replacement therapy will always be more dependent on the expert adjusting the therapy than the formulation itself. The “timing is critical principle” from Parkinson’s Treatment: 10 Secrets to a Happier Life should be considered during dose adjustments for any Parkinson’s disease patient. It is really positive news that drug manufacturers are now listening to Parkinson’s disease patients, and are trying to address the major concerns, though there is a lot of room for improvement and more formulations in the marketplace.

Source: http://www.parkinson.org/find-help/blogs/whats-hot/february-2015

Personal Conclusion: As of today, My wife will not benefit switching from her current immediate release medication since she is taking less than 4 pills a day. Moreover, this new drug is much more expensive than my wife's current immediate released formulation medication.